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doi: 10.1186/s40169-014-0033-2 87 RuysseveldtEMartensKSteelantB

Brequinar, an inhibitor of dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway, was found to suppress tumor growth in xenograft models of SCLC ( Gln-Fructose-6-Phosphate Aminotransferase Gln-fructose-6-phosphate aminotransferase (GFAT) is the rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP), and it will transfer amide nitrogen from Gln to fructose-6-phosphate in the first and subsequently generate amine-6-glucose phosphate (GlcN-6-P)